Larotrectinib discontinuation possible for some paediatric NTRK fusion-positive tumours
Children who respond to larotrectinib therapy for sarcoma with a neurotrophic tyrosine receptor kinase gene fusion may be able to discontinue treatment, indicates research published in the Journal of Clinical Oncology.
Primary MMR deficiency ‘underdiagnosed’ among young people with glioma
Primary mismatch repair deficiency in gliomas is underdiagnosed among people younger than 40 years old, say investigators who recommend assessment of the biomarker to help facilitate checkpoint inhibitor therapy.
Hypertension perseveres from childhood and adolescence to adulthood
High blood pressure or hypertension in childhood or adolescence appears to endure into adulthood, report researchers in findings that support early prevention.
European retinoblastoma report shows stabilised incidence, high 5-year survival
The incidence of retinoblastoma in children in Europe stabilised between 2000 and 2013, say EUROCARE-6 Working Group investigators who report high 5-year survival rates in this population.
Fear of recurrence persists for decades among paediatric cancer survivors
A third of adults who survive childhood cancer continue to have a fear of cancer recurrence for decades after their diagnosis, highlights research published in JAMA Network Open.
Paediatric HCT for nonmalignant illness requires lifelong follow-up
Children and adolescents who undergo allogeneic haematopoietic stem cell transplantation for nonmalignant disease require “multidisciplinary and lifelong follow-up”, researchers recommend in The Lancet Child & Adolescent Health.
Perioperative opioid use in US youths often not in line with guidelines
Many children and adolescents are receiving opioid prescriptions for prolonged periods after inpatient or outpatient surgical procedures, which is outside the guidelines for their use, suggests research published in JAMA Network Open.
Surveillance effective for childhood cancer predisposition syndrome management
Early detection of tumours in children with a cancer predisposition syndrome can be achieved with standardised surveillance protocols, US cohort study findings demonstrate.
Phoenix Sepsis Score ‘accurate’ for children undergoing cancer treatment
The Phoenix Sepsis Score “accurately” characterises the risk of definitely attributable mortality from sepsis and the duration of intensive care unit stay in children undergoing cancer treatment who have a suspected infection, US researchers report.
Lipoprotein apheresis improves cardiovascular survival in HoFH
Patients with homozygous familial hypercholesterolaemia who initiate lipoprotein apheresis during childhood and adolescence have a reduced long-term risk for atherosclerotic cardiovascular disease and death, shows follow-up of two international registries.
